Aim: The aim of this study was to evaluate the clinical efficacy of two apex locators i.e. Propex pixi and Root ZX in comparison with standard radiographic technique in cases with and without lesions.
Methodology: A total of 40 patients scheduled for pulp space therapy with carious intact maxillary molars were taken into the study of which 20 cases with periapical lesions and 20 without periapical lesions were selected and the working length of palatal canal was determined using standard radiographic technique and two apex locators Propex pixi and Root ZX mini.
Results: All the analysis was done using SPSS version 14. A p-value of <0.05 was considered statistically significant. Intra-group comparison was done using repeated measures ANOVA with post-hoc Bonferroni test and inter-group comparison was done using Independent sample t test.
Conclusion: The results of the study concluded that in cases with lesions there was no much significance between the radiographic method and the apex locators whereas in cases without lesions radiographic method consistently showed a higher value when compared to the apex locators.

Key Words: Apex locators, Propex pixi, Root ZX, Periapical lesion, Working length, RVG