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IP Archives of Cytology and Histopathology Research

Melanocytic differentiation in clear cell renal cell carcinoma: a rare case report with review of literature

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Author Details: Ram Nawal Rao, Paramita Paul, Pallavi Prasad, Preeti Chawla, Priyank Yadav

Volume : 2

Issue : 3

Online ISSN : 2456-9267

Print ISSN : 2581-5725

Article First Page : 58

Article End Page : 60


Renal cell carcinoma has been classified into various subtypes with newer emerging entities. The tumors have different cytogenetic, molecular characteristics and recognizing histologic patterns of Renal cell carcinoma(RCC) is important not only for correct diagnosis, but also for providing insight into the biological behavior of the tumor and subsequent appropriate medical care for the patient. Pigments other than hemosiderin have been described in renal cell carcinoma but a very few case reports are there of melanin deposition. Melanotic tumors, either primary or metastatic, are rare in the kidney. Herein we present a rare case of RCC with melanocytic differentiation, a variant that may lead to diagnostic error and may warrant the classification of this entity separately.

Renal cell carcinoma, Melanin, Immunohistochemistry and HMB45