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International Dental Journal of Student Research


The biological effect of the endodontic bioactive cements fast set NeoMTA plus and ProRoot-MTA on osteogenic differentiation of mesenchymal stem cells: A systematic review


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Article Type : Review Article

Author Details: Faisal Alghamdi*

Volume : 7

Issue : 2

Online ISSN : 2278-3784

Print ISSN : 2394-708X

Article First Page : 24

Article End Page : 28


Abstract

Background and Objective: Mineral trioxide aggregates (MTA) is the standard material used in endodontic treatment and different dental specialties as pulp capping, repair for root perforation, retrograde filling restoration, apexification and/or revascularization. The aim of this systematic review is to assess the osteogenic activity of NeoMTA Plus in compared with ProRoot-MTA using mesenchymal stem cells.
Material and Methods: Two automated databases (Google Scholar and PubMed using English-language literature) were used for this systematic review. The electronic search was done in December 2018 and updated in April 2019.
Results: Our inquiry uncovered nine studies that met the exclusion and inclusion criteria. These studies investigated the osteogenic activity of NeoMTA Plus in compared with ProRoot-MTA using mesenchymal stem cells. Most of investigations in this review showed the ProRoot-MTA had a greater osteoinductivity and induced the gene expression by different MSCs exposed to it.
Conclusion: Both NeoMTA Plus and ProRoot-MTA had osteogenic activity when used as endodontic repair material.

Keywords: Bioactivity, NeoMTA, ProRootMTA, Mesenchymal stem cells, Osteogenic differentiation.

Doi :-https://doi.org/10.18231/j.idjsr.2019.006