Article Type : Review Article
Volume : 7
Issue : 2
Online ISSN : 2278-3784
Print ISSN : 2394-708X
Article First Page : 24
Article End Page : 28
Background and Objective: Mineral trioxide aggregates (MTA) is the standard material used in endodontic treatment and different dental specialties as pulp capping, repair for root perforation, retrograde filling restoration, apexification and/or revascularization. The aim of this systematic review is to assess the osteogenic activity of NeoMTA Plus in compared with ProRoot-MTA using mesenchymal stem cells.
Material and Methods: Two automated databases (Google Scholar and PubMed using English-language literature) were used for this systematic review. The electronic search was done in December 2018 and updated in April 2019.
Results: Our inquiry uncovered nine studies that met the exclusion and inclusion criteria. These studies investigated the osteogenic activity of NeoMTA Plus in compared with ProRoot-MTA using mesenchymal stem cells. Most of investigations in this review showed the ProRoot-MTA had a greater osteoinductivity and induced the gene expression by different MSCs exposed to it.
Conclusion: Both NeoMTA Plus and ProRoot-MTA had osteogenic activity when used as endodontic repair material.
Keywords: Bioactivity, NeoMTA, ProRootMTA, Mesenchymal stem cells, Osteogenic differentiation.