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IP International Journal of Aesthetic and Health Rejuvenation


Insulin resistance related to Vitamin D deficiency in gestational diabetes mellitus


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Article Type : Research Article

Author Details: Shaik Mahmood*

Volume : 2

Issue : 1

Online ISSN : XXXX

Print ISSN : XXXX

Article First Page : 11

Article End Page : 13


Abstract

Introduction: Beta cells in the pancreas secrete insulin, C-Peptide. C-Peptide is marked as an indicator of insulin secretion. Dysregulation of insulin - mediated metabolic pathways has emerged as an underlying malfunction through which vitamin D deficiency in gestational diabetes may be linked. Vitamin D deficiency is also associated with resistance and pancreatic beta cell dysfunction. Vitamin D activity increases insulin release and insulin secretion from pancreatic islet bet cells. C – Peptide hormone is an indicator of insulin secretion and is a connecting peptide. It is removed when insulin is released and secreted in the first and second phases of insulin secretion. Optimal vitamin D homeostasis may be essential for both insulin secretion and action, two fundamental features in the pathogenesis of insulin resistance and diabetes. The present study was designed to demonstrate the relationship between 25 – Hydroxyl Vitamin D (25 (OH)D) Levels and Insulin Resistance (IR) in normal pregnancy and Gestational Diabetes Mellitus (GDM). The study included 150 pregnant women classified into two main groups normal present (n=100) and GDM (n=50). Further classification for each group was carried out based on 25(OH)D, Fasting Blood Glucose (FBG), Fasting Insulin (FI) C – Peptide and Insulin Resistance (IR) markers were calculated including Glucose / Insulin ration (G/I). Results indicated significantly increased FBG, FI, C-Peptide compared to control group, no significant correlations were obtained between 25(OH)D and any tested parameters, however, in GDM 25(OH)D showed significant corrections with FBG. Thus this indicating that 25(OH)D way be associated with elevated IR that accompanying GDM.

Keywords: Gestational diabetes mellitus, Vitamin D, Insulin resistance, C – Peptide.