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Indian Journal of Clinical Anaesthesia

A Clinical Study of Dexmedetomidine under Combined Spinal Epidural Anaesthesia at a Tertiary Care Hospital

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Author Details: Kamala GR, Leela GR

Volume : 2

Issue : 4

Online ISSN : 2394-4994

Print ISSN : 2394-4781

Article First Page : 196

Article End Page : 203


Introduction: Sedation has been shown to increase patient satisfaction during regional anesthesia and may be considered as a means to increase the patient’s acceptance of regional anesthetic techniques. For surgery under regional anesthesia, sedation is a valuable tool to make it more convenient for the patient, the anesthetist, and the surgeon. This study focuses sedative property of Dexmedetomidine in regional anesthesia.
Material and Method: This study was conducted in the Department of anaesthesiology, Banaras Hindu University. A randomized prospective study was conducted on 60ASA grade I and II patients of age 20 to 60 years undergoing elective gynaecological surgery. Dexmeditomidine was administered intravenously for sedation. Group A sedation was monitored by BIS and Group B by Ramsay sedation score (RSS).
Results: The induction, maintenance and total dose of Dexmedetomidine in group A was significantly less than in group B (28.77±4.44 vs 35.43±6.90, 12.24±2.70 vs 18.57±4.74, and 41.01±5.97 vs 54.00±9.62 mcg p< 0.001). Recovery time was prolonged in group B in comparison to group A (37.87±3.35 vs 22.17±3.19 mins p<0.001). Vitals like heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure were significantly less than baseline in both groups. Respiratory rate and SPO2 did not change significantly from baseline in both groups.
Conclusions: Dexmedetomidine provides effective sedation. Use of BIS during Dexmedetomidine infusion reduces the dose required for sedation.

Keywords: Dexmedetomidine, BIS, RSS, Combined spinal epidural anaesthesia, Sedation