Indian Journal of Clinical Anaesthesia

Comparative study of efficacy of combination of palonosetron hydrochloride & dexamethasone sodium phosphate versus dexamethasone sodium phosphate alone for postoperative nausea & vomiting after modifi

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Author Details: Bijal M Shah, Nita D Gosai, Rashmi Ranjan Dash, Krupa D Kalaria, Bipin M Patel

Volume : 3

Issue : 2

Online ISSN : 2394-4994

Print ISSN : 2394-4781

Article First Page : 160

Article End Page : 164


Background: Post-operative nausea & vomiting is a common and distressing complaint observed after Modified Radical Mastectomy surgery performed under General Anaesthesia.
We compare the effect of combined palonosetron (0.075 mg) & dexamethasone (8mg) versus dexamethasone(8mg) administered i.v. alone for controlling post-operative nausea & vomiting in MRM Patients by means of a Randomized double blind control study.
Materials & Method: In a prospective randomized study 50 patients of ASA I and ASA II undergoing elective Modified Radical Mastectomy under general anaesthesia were allocated in two groups(25 patients in each).
Group A (Dexona Group) received 8 mg dexona before induction of anaesthesia.
GroupB (Palonosetron +dexona Group) received IV DEX 8mg+Palonosetron 0.075 mg before induction of anaesthesia
The incidence of PONV, need for rescue antiemetics and complete response was recorded at the end of 0,2,4, 6 hr,12 hrs,24 hrs.
Results: The incidence of complete response (no PONV, no rescue medication) was 88% (p=0.025) for the early post-operative period (0-6 h) in the combination P+D group and 84% (p=0.032)for the late (6-24 hr) period as compared to 56% and 52% in the dexona only group in the early (0-6h) and the late (6-24h) post-operative period respectively.
Conclusion: Palonosetron –DEX combined regimen given before anaesthesia induction is an effective regimen for early (0-6 hr) and late (6-24 hr) PONV with significantly lower incidence of PONV, higher incidence of complete response and better patient satisfaction.

Key words
:  Palonosetron, Dexamethasone, Modified radical mastectomy