Indian Journal of Clinical Anaesthesia


Role of IV Nalbuphine in attenuation of haemodynamic response to laryngoscopy and endotracheal intubation


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Author Details: Dnyaneshwar Ramaji Fating, Ashwini K. Dandekar, N.G. Tirpude

Volume : 3

Issue : 2

Online ISSN : 2394-4994

Print ISSN : 2394-4781

Article First Page : 165

Article End Page : 169


Abstract

Background: Laryngoscopy and endotracheal intubation evoke a haemodynamic response leading to increased heart rate and blood pressure. Purpose of present study was to evaluate the efficacy of Nalbuphine for attenuation of haemodynamic response to laryngoscopy and intubation.
Methods: 120 patients belonging to ASA Grade I and II, posted for elective laparoscopic surgery under general anaesthesia were included in this double blind prospective randomised study. Patients were randomly allocated in two groups to receive either injection Nalbuphine IV 0.2mg/kg diluted to 5 ml with normal saline (Group N) or 5 ml normal saline (Group C), five minutes before induction. Monitoring of heart rate, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure was done at laryngoscopy and endotracheal intubation and 1, 3, 5, 7 and 10 minutes after laryngoscopy and endotracheal intubation.
Results: Increase in heart rate, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure in Group N was lower than in Group C.
Conclusion: Intravenous Nalbuphine in the dose of 0.2 mg/kg appears to be a promising drug which can be used to attenuate the haemodynamic response to laryngoscopy and intubation.

Keywords:
Nalbuphine, Haemodynamic response, Laryngoscopy, Intubation, Heart Rate and Mean arterial blood pressure