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Indian Journal of Clinical Anaesthesia


A double blind study comparing the effect of intravenous rabeprazole and pantoprazole on gastric pH and volume in laparoscopic surgery under general anaeshesia


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Author Details : Sumalatha GB, Ravichandra Ramesh Dodawad

Volume : 3, Issue : 4, Year : 2016

Article Page : 529-533


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Abstract

Background and Aims: Major thrust in reducing potential for acid aspiration is increase the pH by various methods and pharmacological agents. The aim of the study is to compare the effectiveness of intravenous rabeprazole and pantoprazole on gastric volume and pH in patients undergoing elective laparoscopic surgery under general anesthesia.
Materials and Methods: Sixty patients of either sex, aged 18-55 yr, ASA physical status I or II, undergoing elective laparoscopic surgery were randomly assigned in to Group R and Group P to receive intravenous 20mg rabeprazole and 40 mg pantoprazole 15 min before induction of anaesthesia. The post-intubation and pre-extubation gastric aspiration volume and pH was measured with pH meter.
Results: The mean post-intubation volume was 20.52±4.46ml and 22.48±4.33 in group R and group P respectively. The mean pre-extubation volume in group P and group R was 15.14±3.66 and 11.10±2.84 respectively. The mean pH of post-intubation gastric aspiration contents in group P was 6.41±0.69 and in group R was 7.37±0.56. All values were statistically significant (p<0.05).
Conclusion: Intravenous rabeprazole is more effective than pantoprazole in reducing the gastric volume and increasing the gastric pH.

Keywords:
Rabeprazole, Pantoprazole, Gastric volume, pH

How to cite : Sumalatha Gb, Dodawad R R, A double blind study comparing the effect of intravenous rabeprazole and pantoprazole on gastric pH and volume in laparoscopic surgery under general anaeshesia. Indian J Clin Anaesth 2016;3(4):529-533

Copyright © 2016 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)