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Indian Journal of Clinical Anaesthesia

To Evaluate the Efficacy and Safety of Dexmedetomidine on Hemodynamic Stability in Patients Undergoing Laproscopic Cholecystectomy

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Author Details: Sapna Bansal, Sachin Bansal, Shruti Saini, Dhanwant Kaur, Apoorva Kaul, Jaggy

Volume : 2

Issue : 3

Online ISSN : 2394-4994

Print ISSN : 2394-4781

Article First Page : 146

Article End Page : 150


Introduction: Peritoneal insufflation of intra-abdominal pressure >10 mmHg induces a significant alteration of hemodynamics. Use of α-2 adrenergic agonists Dexmedetomidine significantly reduces hemodynamic changes and anesthetic requirements as it has sedative, analgesic, and anxiolytic properties.

Methods: 100 patients of ASA I- II undergoing laparoscopic cholecystectomy were randomly allocated into two groups of 50 patients each. Group I patients received dexmedetomidine infusion at 0.2μg/kg/hr and Group II patients received normal saline infusion at 0.2μg/kg/h starting after intubation and continued till peritoneal deflation. Parameters noted were pulse rate, mean arterial pressure, oxygen saturation, EtCO2 and isoflurane requirement.
Results: In dexmedetomidine group, the haemodynamic response was significantly attenuated. The anaesthetic requirement was also less with dexmedetomidine group without any desaturation.
Conclusion: Dexmedetomidine infusion in the dose of 0.2μg/kg/h effectively attenuates haemodynamic stress response to pneumoperitoneum during laparoscopic surgery.

Key words: Dexmedetomidine, haemodynamic stress response, laparoscopic cholecystectomy, pmeumoperitoneum.