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Indian Journal of Clinical Anaesthesia

Comparison of injection ondansetron with granisetron on maternal haemodynamics and regression of sensory and motor blockade in elective caesarean section: A randomised non inferiority exploratory trial

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Article Type : Research Article

Author Details: Debanjali Ray,Mrinal Saha,Asoke Chakraborty*,Mohan Chandra Mandal

Volume : 6

Issue : 3

Online ISSN : 2394-4994

Print ISSN : 2394-4781

Article First Page : 328

Article End Page : 331


Introduction: Spinal anesthesia has many advantages for cesarean section in parturients, but hypotension is considered the most frequent complication and can be managed by different interventions. Hypotension may be induced by sympathetic blockade and Bezold-Jarisch reflex (mediated by peripheral serotonin receptor, 5-HT3 type). Besides, early regression of sensory and motor blockade are also necessary to prevent various complication. It has been found that level of serotonin is increased in cerebrospinal fluid after spinal anaesthesia. So use of 5HT 3 anatagonist can have effect on both.

Objectives: To compare between two serotonin receptor antagonists on the hemodynamics, sensory, and motor blockade induced by intrathecal bupivacaine in parturients undergoing cesarean section.

Materials and Methods: Fourty four patients undergoing elective cesarean section under spinal anesthesia by intrathecal bupivacaine were randomly divided into two groups (22 pregnant females of ASA I–II physical status in each group). Group O received intravenous 8 mg ondansetron diluted in 8 ml normal saline and injected 5 min before spinal anesthesia, group G given intravenous 1 mg granisetron in 8 ml normal saline by the same route. Mean arterial blood pressure, heart rate, vasopressor use, sensory and motor blockade were assessed.

Results: use of vasopressors was significantly low in group O (p<0>

Conclusion: In parturient females undergoing elective cesarean section, intravenous 8 mg ondansetron significantly reduces the demand of vasopressors and ganisetron 1 mg provides faster recovery from sensory and motor blockade.

Keywords: Ondansetron, Granisetron, Haemodynamics, Sensory and motor blockade.

Doi :-https://doi.org/10.18231/j.ijca.2019.063