Indian Journal of Clinical Anaesthesia

Effects of magnesium sulphate on intraoperative neuromuscular blocking agent requirement: A prospective randomized double blind placebo controlled study

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Article Type : Research Article

Author Details: Aabid Hussain Mir,Juvera Gul Wani,Abida Yousuf*,Sheikh Irshad,Zahoor Ahmad Shah

Volume : 6

Issue : 3

Online ISSN : 2394-4994

Print ISSN : 2394-4781

Article First Page : 355

Article End Page : 358


Introduction: Magnesium sulphate has been shown to decrease intraoperative anesthesia, analgesia and muscle relaxant requirements.
Aims: To study the effects of intraoperative magnesium sulphate on requirement of neuromuscular blocking agents.
Setting and Design: This prospective randomized double blind placebo controlled study was conducted in the department of Anaesthesiology and Critical Care of a tertiary care centre.
Materials and Methods: 50 patients of ASA physical status I and II were randomly allocated into two groups, magnesium group (Group M) received magnesium sulphate 50 intravenously as a bolus in 100 ml of isotonic saline over 10 minutes before induction of anesthesia and 15 by continuous infusion during the operation and the control group (Group S) received the same amount of isotonic saline over same time. Atracurium was administered 0.6 before intubation and 0.1 additionally when train-of-four counts were 2 or more intravenously. The consumption of atracurium was compared in both groups.
Statistical Analysis: The variables were analysed with independent t-test, Wilcoxon-Mann Whitney U- test and chi-square test. P-value<0> Results: The mean consumption of atracurium in group M was 0.35±0.11 and group S was 0.47±0.19 with p-value<0> Conclusion: Intravenous magnesium sulphate reduces atracurium requirements in patients undergoing abdominal surgeries under general anesthesia.

Keywords: Neuromuscular blocker, Intraoperative, Magnesium, Atracurium.

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