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IP International Journal of Comprehensive and Advanced Pharmacology


Posterior Reversible Encephalopathy Syndrome (PRES): A reversible neurological disorder an analysis through case series


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Author Details: Sajith Sebastian, Jenny Susan Roy, Catherine

Volume : 1

Issue : 1

Online ISSN : 2456-9542

Print ISSN : 2581-5555

Article First Page : 10

Article End Page : 13


Abstract

Background: Aim of the study was to analyze 3 cases of PRES, a relatively uncommon disorder which is completely reversible and presenting as encephalopathy during a period of two year in a tertiary neurological centre in South India.
Material and Method: Total of 3 cases of PRESyndrome were analysed retrospectively in a period of 2 yrs during January 1, 2014 to January 1, 2016 to assess the various presentations of this rare syndrome and their outcomes. Cases were studied in detail including complete history, clinical examination and other findings were recorded.
Result: out of f 3 patients diagnosed with PRES were females between age of 19-29 years and were 5-8 days post partum. 66.6% presented as GTCS. 33.3% had history of systemic hypertension while 33.3% had a history of PIH and GDM. Only 33.3% presented with very high blood pressures on admission. MRI was diagnostic and suggested sub cortical vasogenic edema in all. All of the 3 patients recovered completely without residual neurological deficit or else required long term treatments.
Conclusion: PRES should be considered in patients who present with symptoms of seizures / convulsions, alter in consciousness, visual disturbances and or headache, particularly if associated with acute hypertension. PRES has commonly seen in patients with chronic and acute kidney disease, solid organ transplantation, and use of immuno-suppressive drugs. Typical MRI findings include reversible, symmetrical, posterior subcortical vasogenic edema. If recognized and treated early, the rapid onset symptoms and radiologic features usually completely resolve within days to weeks.

Keywords:
Encephalopathy, Systemic Hypertension, Headache