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IP International Journal of Comprehensive and Advanced Pharmacology


Attenuation of depression by Bauhinia purpurea linn. leaves ethanolic extract in swiss albino mice


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Author Details: Prathvi Shetty, Manohar V.R., Sara Kurien, Mohandas Rai

Volume : 2

Issue : 3

Online ISSN : 2456-9542

Print ISSN : 2581-5555

Article First Page : 85

Article End Page : 87


Abstract

Introduction: Depression is a characterised by low mood and lack of activity that can implicit on person's thoughts, behaviour, feelings, and sense of well-being.
Objectives: To evaluate antidepressant activity of Ethanolic extract of Bauhinia Purpurea in Swiss Albino mice.
Materials and Method: Sixty Swiss Albino mice of either sex weighing 20-25gm were divided into five groups, Group I received vehicle (1% Gum acacia suspension - 3ml/kg P.O), Group II received standard drug Imipramine (10mg/kg orally 1 hour before the experiment). Group III, IV, V received the test drug in the dose of 100 mg/kg, 250mg/kg, and 500mg/kg respectively. Experiment was done by Forced swim test (FST) and Tail suspension test (TST) and duration of mobility and immobility were considered during the last 4 minutes in the 6 minutes test.
Statistical analysis: Dunnett’s test. P < 0.05 was considered as significant.
Results: Administration of ethanolic extract of Bauhinia Purpurea at the dose of 500mg/kg produced significant decrease in immobility time in both the models with a P value of < 0.05.
Conclusion: Administration of ethanolic extract of Bauhinia Purpurea at the dose of 500mg/kg has produced statistically significant decrease in immobility time in both the models.