Indian Journal of Clinical Anatomy and Physiology

Localization of gap junction and neuropeptide as a determinant of neuropathic pain

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Author Details: Karthikeyan G, Sankaran PK, Kumaresan M, Zareena Begum, Yuvaraj M

Volume : 4

Issue : 2

Online ISSN : 2394-2126

Print ISSN : 2394-2118

Article First Page : 259

Article End Page : 262


Introduction: The trigeminal ganglion consists of pseudounipolar neurons surrounded by satellite glial cells and processes innervating craniofacial region. The gap junctions are transmembrane proteins formed between the cell membranes of adjacent cells and calcitonin gene related peptide are neuropeptides secreted by sensory neurons.
Aim and Objective: In present study the immunohistochemical localization for connexin 43 gap junctions and CGRP was done in the trigeminal ganglion of male Wistar rats.
Result: The result showed connexin 43 was present between the satellite glial cells, between satellite glial cell and neuron and in the Schwann cells. CGRP was localized densely in the cytoplasm of small neurons.
Conclusion: The excited neuron can influence the surrounding satellite glial cells and neurons through gap junctions and by paracrine actions altering its environment leading to pathological role in inducing painful conditions like migraine.

: Gap junctions, CGRP, Trigeminal ganglion, Migraine, Connexins