Indian Journal of Clinical Anatomy and Physiology


Role of estrogen on autonomic functions of postmenopausal women


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Author Details: Vijaya Lakshmi M

Volume : 4

Issue : 4

Online ISSN : 2394-2126

Print ISSN : 2394-2118

Article First Page : 562

Article End Page : 565


Abstract

Introduction and Objectives: Menopause is part of the aging process which is characterized by the natural cessation of menstruation. During this time the reduction in estrogen can cause symptoms and disorders that can interfere with their quality of life. Women are also more susceptible to cardiovascular diseases during this period that these ovarian hormones would be associated with a protective effect on the cardiovascular system. Postmenopausal women are at risk of developing cardiovascular complication associated with alterations in autonomic nerve functions. Thus, this study was aimed to test the role of estrogen in postmenopausal women that alters the autonomic functions.
Materials and Method: Healthy premenopausal and postmenopausal women with the age group of 40-55yrs were selected for the study. Parameters like Pulse rate, Blood pressure, Cold pressor test, Orthostasis for sympathetic functions and Heart rate response-difference, Standing/lying ratio, 30:15 ratio for parasympathetic functions are recorded. Serum estrogen was done for both the groups.
Results: There was a significant increase in the sympathetic activity and reduced parasympathetic activity in postmenopausal women. Sr.estrogen levels were reduced in postmenopausal women. Parameter 30:15 ratio, showed positive correlation with and Orthostasis showed negative correlation with Serum estrogen level in postmenopausal women.
Statistical Analysis: By student ‘t’ test and Pearson Coefficient of Correlation.
Conclusion: There was a significant increase in the sympathetic activity and reduced parasympathetic activity in postmenopausal women due to decreased level of estrogen.

Keywords:
Estrogen, Autonomic functions, Post-menopausal women