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Indian Journal of Clinical Anatomy and Physiology

Improvement in lipid profile of the patients with saxagliptin as add on therapy to metformin in patients of type 2 DM who were previously on metformin alone with uncontrolled diabetes

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Author Details: Akshay Dahiwele, Dinesh Kansal, Dheeraj Kapoor, Parveen Sharma

Volume : 3

Issue : 1

Online ISSN : 2394-2126

Print ISSN : 2394-2118

Article First Page : 10

Article End Page : 12


Introduction: Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. This study is an attempt to show an improvement in lipid profile (TC, TG, LDL and HDL) in patients of type 2 diabetes mellitus who were previously on metformin monotherapy with uncontrolled diabetes.
Material and method: A total of 30 patients were enrolled who were on metformin monotherapy and with uncontrolled diabetes. Patients were given metformin 500 mg twice a day and saxagliptin 2.5 mg once a day.
Patients were followed up at 1st, 3rd and 6th month and lipid profile (TC, TG, LDL and HDL) estimation was done during the follow up period.
Results: The mean age ± SD in male and female patients was 61.42 yrs ± 6.99 and 55.93 yrs ± 5.74 respectively. The mean change in value from baseline at 24 weeks was TC = 9.66%, TG = 9.40%, LDL = 14.87%, HDL = 5.63%. A highly significant difference has been seen at 0 v/s 1, 0 v/s 3 and 0 v/s 6 months in TC, TG, LDL and HDL values.
Conclusion: Saxagliptin has shown an improvement in lipid profile (TC, TG, LDL, HDL) during 6 months of treatment in patients of type 2 DM.

Keywords: Saxagliptin, Uncontrolled type 2DM, Metformin, Lipid profile.

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