International Journal of Clinical Biochemistry and Research


Study of total and free thyroid hormone levels in chronic renal failure


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Author Details: Mohammed Shamsuddin, Netravathi Sajjan

Volume : 3

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 31

Article End Page : 35


Abstract

The study is undertaken to estimate the total and free thyroid hormone levels i.e. TT3, TT4, FT3, FT4 & TSH and thyroid dysfunctions in chronic renal failure. The study also includes the thyroid abnormalities in relation to varying grades of CRF (serum creatinine). A cross sectional study was conducted consisting of 30 male patients of aged between 40-70yrs having serum creatinine > 4.0mg/dl & urea > 50mg/dl with frank proteinuria and symptoms & signs suggestive of CRF are taken in study. Serum levels of TT3, TT4, FT3, FT4 & TSH are estimated by chemiluminesence immune assay method, and the data obtained by the study subjects were compared with data from normal individuals of same age group using student t test. We got the results that TT3, TT4, FT3, FT4 decreases TSH increases significantly in study group compare to normal individuals i.e. controls. Out of 30 patients in study group 3 patients (10%) are in hypothyroid range. The hormone levels of TT3, TT4 and FT3, FT4 decreases and the levels of TSH increases as severity of CRF increases. We finally concluded that Total and free thyroid hormone levels decreases and TSH increases in CRF compare to controls even though are majority them are euthyroid. CRF is associated with increased risk of hypothyroidism and this risk increases as severity of disease increases.

Keywords:
Chronic renal failure, Chronic Kidney Disease, End Stage Renal Disease, Hypothyroidism, Thyroid hormones, Thyroid Stimulating Hormone(TSH)