International Journal of Clinical Biochemistry and Research


A Correlation Study between Plasma Neutrophil Gelatinase Associated Lipocalin and Serum Creatinine in Cardiac Surgery Patients


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Author Details: Anusha.R, Madhubala.V

Volume : 3

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 72

Article End Page : 75


Abstract

Background & objectives: Neutrophil Gelatinase Associated Lipocalin NGAL predicts Acute Kidney Injury earlier than creatinine in cardiac surgery patients. This study aims at understanding the correlation between the two biomarkers.
Methods: 53 patients who underwent major cardiac surgery were included in the study. Venous blood samples were collected before surgery and at 4 hours after surgery to estimate plasma NGAL and before surgery, at 4 hours, 24 hours, 48 hours and 72 hours after surgery from the patients to estimate serum creatinine. Correlation analysis was done between NGAL and creatinine using Pearson Correlation Coefficient.
Results: The correlation coefficients for plasma NGAL values at 4 hours after surgery with the serum creatinine values were r = 0.87 at 4 hours, r = 0.86 at 24 hours, r = 0.91 at 48 hours and r = 0.87 at 72 hours after surgery.
Interpretation: The correlation coefficient values shows that plasma NGAL values at 4 hours after surgery were highly correlated with the serum creatinine values at 4 hours, 24 hours, 48 hours and 72 hours after surgery.
Conclusion: This study shows that NGAL values are highly correlated with creatinine values.

Keywords:
NGAL, Creatinine, Aki, Cardiac Surgery