International Journal of Clinical Biochemistry and Research


Comparative study of lipid profile & lipid peroxidation in normal pregnant subjects & subjects with pre-eclampsia


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Author Details: N.Jaya, M.Girija Menon, N.Chowdeshwari, B.V Rama Rao

Volume : 3

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 110

Article End Page : 113


Abstract

Background: It is the increased responsiveness of the arterial system to pressor substances which probably causes the generalized vasoconstriction and hypertension of pre-eclampsia. In normal human pregnancy, there is decreased blood pressure response to pressor materials, but in pre-eclampsia there is marked increase in response to vasopressin1 to norepinephrine and to angiotensin.
Objective: To Compare lipid profile & lipid peroxidation in normal pregnant subjects & subjects with pre-eclampsia.
Methods: This study has been undertaken to correlate hyperlipidemia with lipid peroxidation with PIH/Eclampsia among 65 women. This study was carried out in the department of Biochemistry and Gynecology and Obstetrics at Osmania Medical College and Hospital Hyderabad.
Results: Pregnancy with pre-eclampsia showed an obvious and significant increase in the mean levels of serum malondialdehyde, serum triglyceride, mean serum levels of cholesterol, mean serum sodium levels when compared to the control group.
Conclusion: Lipid peroxidation as an important factor in pathogenesis of pregnancy induced hypertension is discussed.

Key words:
lipid profile, lipid peroxidation, pregnant subjects