International Journal of Clinical Biochemistry and Research


The association of serum uric acid with total white blood cell count in a healthy Indian adult population


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Author Details: Sathya Selvarajan, Jothimalar R, Santhi Silambanan

Volume : 3

Issue : 3

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 304

Article End Page : 307


Abstract

Background: Atherosclerosis is the underlying cause for nearly all cases of Coronary Artery Disease (CAD) which is a major cause of mortality in men and women. Numerous studies state that the basic pathology behind atherosclerosis is inflammation and oxidative stress. Though uric acid is an anti oxidant, recently studies show that it can be transported across the cell membrane and exert harmful intracellular actions such as oxidation and inflammation. These observations led to many epidemiological studies suggesting that uric acid is linked to and may be a risk factor for CAD. The aim of this study was to evaluate whether there is an association between serum uric acid and total white blood cell count, a simple marker of inflammation, in a healthy Indian adult population.
Method: This is a cross sectional study. Samples were collected for assaying serum uric acid, total white blood cell count and plasma glucose, along with the medical history from 203 apparently healthy individuals who attended health examination at Sri Ramachandra Medical Centre in Chennai.
Result: The results obtained were subjected to statistical analysis in SPSS software version 16. There was a strong positive correlation between uric acid and total white cell count and the study revealed no significant difference in mean levels of uric acid in tobacco users and non-users. And there was no statistically significant difference between genders in the mean uric acid level.
Conclusion: A strongly positive correlation was found between serum uric acid and total white cell count, both in men and women. It appears likely that additionally larger well designed prospective studies that adjust for all possible confounding factors may help to strongly establish the correlation between serum uric acid and total white cell count and their role in pro-inflammatory states as in atherosclerosis.

Keywords
: Uric acid, White blood cell count, Inflammation, Coronary artery disease, Atherosclerosis