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International Journal of Clinical Biochemistry and Research


Role of biomarker of Oxidative stress in preeclampsia


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Author Details : Smita Bahediya, Gaurav Modi, Shobha Chokshi

Volume : 3, Issue : 3, Year : 2016

Article Page : 312-315


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Abstract

Objective: To evaluate the role of biomarker of oxidative stress in predilection of pregnancy induced hypertension.
Material and Methods: A sample of 200 pregnant women was examined at department of Gynecology and obstetrics at tertiary care hospital from the period of July 2008 to march 2010. Pregnant women were divided into three groups including 100 normal healthy pregnant women which were controls. Another 100 pregnant women having increased blood pressure and proteinuria divided into two groups depend on severity on B.P. and urinary proteinuria. Groups were compared for the levels of antioxidant biomarker for the statistical analysis, suitable test for these qualitative variables with 5% significance were used.
Results: Preeclampsia remains a frequent and potentially dangerous complication of pregnancy. The cause remains largely unknown, but oxidative stress and a generalized inflammatory state common are features. In present study, patient with pregnancy induced hypertension shows MDA levels were found significantly higher, while Vitamin C and Vitamin E levels are significantly lower compared with normal healthy pregnant women.
Conclusion: A combination of vitamins C and E administration can be found promising for prevention of preeclampsia. As small study group, our study has a limited statistical power if significance several multicenter randomized clinical trials are further required.

Key Words:
Preeclampsia, Oxidative stress, Antioxidants, Free radicals

How to cite : Bahediya S, Modi G, Chokshi S, Role of biomarker of Oxidative stress in preeclampsia. Int J Clin Biochem Res 2016;3(3):312-315

Copyright © 2016 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)