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International Journal of Clinical Biochemistry and Research


Association of serum amylase with insufficient insulin action in Type I and Type II Diabetes Mellitus and Metabolic syndrome


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Author Details : Chandana G, Nina M. Veigas, Raghavendra DS

Volume : 3, Issue : 4, Year : 2016

Article Page : 421-425


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Abstract

Background: Metabolic syndrome (MetS) and Diabetes mellitus (type I and type II) are emerging as epidemics among non communicable diseases. A lot of research has been done on hyperglycemia in Diabetes mellitus and Metabolic syndrome, but very few studies on pancreatic exocrine function have been conducted in these conditions. Therefore, the present study is an attempt to link endocrine and exocrine parts of the pancreas by investigating the association of serum amylase with insufficient insulin action in clinical settings.
Objectives: To estimate and compare serum amylase and insulin levels in Metabolic syndrome and in type I Diabetes mellitus and type II Diabetes mellitus.
Materials and Methods: The subjects included in this study were divided into 3 groups. Group I consisted of 30 Diabetes mellitus Type I patients aged ≤ 25 yrs. Group II consisted of 30 patients of Diabetes mellitus Type II aged ≥ 40 yrs and Group III consisted of 30 Metabolic syndrome patients aged ≥ 40 yrs. Serum insulin, Serum amylase, Fasting blood sugar (FBS) and lipid profile were measured using autoanalyser. Statistical package for social science software version 15 was used for statistical analysis.
Results: Serum amylase was significantly less in DM Type I (40.53±16.58) compared to both DM Type II (75.13±44.81) and Metabolic syndrome (58.77±17.45). The insulin levels were lowest in DM Type I compared to both DM Type II and MetS. In DM Type I, there was a positive correlation between insulin & amylase levels. In DM Type II and MetS there was a positive correlation between insulin & amylase levels at low insulin levels of ≤10 µIU/ ml and negative correlation with insulin résistance i.e. the serum amylase was lower with higher insulin résistance than with moderate insulin resistance.
Conclusion: Our results suggest a significant association between serum amylase levels and insufficient insulin action either due to inadequate insulin secretion and/or insulin resistance in Type I DM, Type II DM and MetS. This indicates a possible exocrine-endocrine relationship in these clinical conditions. Low serum amylase is associated with decreased basal insulin levels and insulin secretion, as well as high insulin resistance than with moderate resistance. Low serum amylase suggests exocrine pancreatic insufficiency and if pancreatic amylase replacement therapy is given to these patients it may improve the nutritional status and also analysis of serum amylase could provide valuable information regarding prognosis of the illness.

Keywords:
Metabolic Syndrome, Amylase, Insulin, Diabetes mellitus Type I, Diabetes mellitus Type II

How to cite : Chandana G, Veigas N M, Raghavendra Ds, Association of serum amylase with insufficient insulin action in Type I and Type II Diabetes Mellitus and Metabolic syndrome. Int J Clin Biochem Res 2016;3(4):421-425

Copyright © 2016 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)