International Journal of Clinical Biochemistry and Research


Vitamin D status and its association with diabetes mellitus in population of Udaipur


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Author Details: Deepa Singh

Volume : 4

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 19

Article End Page : 21


Abstract

Studies have shown that Vitamin D is necessary for normal insulin secretion. Vitamin D reduces insulin resistance through regulation of the insulin receptor gene and its effects on calcium and phosphorus metabolism. Therefore, deficiency of vitamin D results in decreased insulin secretion and increased insulin resistance, both of which are characteristics of type 2 Diabetes mellitus. The predisposition of Vitamin D deficiency to Glucose intolerance via altered insulin secretion may be done either through a direct action via Vitamin D receptor (VDR) activation or indirectly via calcemic hormones and also via inflammation. The study is aimed to measure and correlate Vitamin D status with serum level of fasting and postprandial Glucose, Total Cholesterol and Triacylglycerol level in individuals of Udaipur. The study was carried out on total 300 vegetarian subjects, out of which 190 were females and 110 were males with an average age of 54.25±8.94 years. Subjects were divided into two categories depending upon their serum total Vitamin D value. Category A included subjects with total Vitamin D value below 10 ng/ml and category B included subjects with total Vitamin D value between 30-70 ng/ml. The subjects with total Vitamin D value between 10-30 ng/ml were excluded from the study. Results clearly indicated that Category A with Vitamin D value below 10 ng/ml had significantly higher serum fasting, post prandial Glucose, Total Cholesterol and Triacylglycerol level as compared to subjects with Vitamin D value between 30-70 ng/ml (category B) with significance (p value <0.05). Vitamin D deficiency can lead to dysregulation of Glucose and lipid metabolism. Supplementation of Vitamin D in Vitamin D deficient individuals may reduce the risk of Diabetes mellitus and dyslipidaemia by improving insulin secretion and Glucose tolerance.

Keywords:
Vitamin D, Insulin Resistance, Dyslipidaemia, Type 2 Diabetes mellitus