International Journal of Clinical Biochemistry and Research


A study on role of Oxidative stress and Calcium-Phosphorous Ratio in Rheumatoid Arthritis


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Author Details: Pullaiah Akinepalli, Mahesh Gajula, Narender G

Volume : 4

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 39

Article End Page : 42


Abstract

Background: Rheumatoid arthritis is one of the chronic inflammatory disease affecting joints and other organs is primarily of an unknown etiology with an incidence of 1% to 2% of total world population.one of the current school of thought implies oxidative stress related to free radical damage, auto immunity and genetic predisposition are few of the important etiological factors proposed for its causation. The current study is aimed to see whether detection of lipid peroxidation products such as Malondialdehyde(MDA) and estimation of serum calcium, phosphorous, Alkaline phosphatase, calcium-phosphorous ratio as biomarkers for Rheumatoid Arthritis that will help to diagnose and treat disease at an early stage.
Material and Methods: The current study is prospective study carried out at Kakatiya Medical College and Mahatma Gandhi Medical College, Warangal from January 2014 to January 2015 over 100 subjects of which 50 cases were suffering with Rheumatoid arthritis while 50 subjects were normal healthy adults. Data was recorded in a pretested proforma and was analyzed using appropriate statistical methods.
Results: During the study, it is found that there is raise in mean MDA levels in the group suffering with Rheumatoid arthritis (p value <0.001) when compared to control group. Similarly, the serum calcium levels are found decreased, serum phosphorous levels were increased in the subjects suffering with Rheumatoid Arthritis. The difference between the means of two groups in relation to Calcium-phosphorous ration was found to be statistically significant (p < 0.001).
Conclusion: In conclusion, the increased MDA levels in the present study may be considered as important marker but apparently not sufficient to conclude that there was an increase in oxidative stress in rheumatoid arthritis patients.

Keywords
: Malondialdehyde (MDA), Rheumatoid Arthritis, Serum Calcium, Serum Phosphorous, Calcium-Phosphorous ratio