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International Journal of Clinical Biochemistry and Research

Thyroid function parameters, body mass index and serum lipid profile in subclinical hypothyroidism: a hospital-based study of effect of levothyroxine replacement therapy in Srinagar, Jammu and Kashmir

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Author Details: Rama Jailkhani, AR Shivashankara, Manjot Sahni, JB Honnamurthy

Volume : 4

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 94

Article End Page : 98


Introduction: The Present study aimed to assess the effect of levothyroxine replacement therapy on serum lipid profile and thyroid function parameters of patients on subclinical hypothyroidism. We also aimed to correlate the lipid profile parameters with body mass index.
Methods: Ninety patients of subclinical hypothyroidism treated with levothyroxine for three months were included in the study. Fifty three euthyroid subjects served as controls. Levels of serum TSH, total cholesterol were assayed before and after levothyroxine therapy in patients with subclinical hypothyroidism. Levels of serum TSH, total cholesterol, LDL-cholesterol, HDL-cholesterol, T3 and T4 in subclinical hypothyroidism patient’s post-levothyroxine therapy were compared with those of euthyroid controls, and correlated with body mass index.
Results: The study demonstrated significant decrease in serum total cholesterol levels in subclinical hypothyroidism patients on levothyroxine treatment (P <0.001). Male hypothyroid subjects showed significantly lower serum triglycerides, post thyroxine therapy, when compared to euthyroid males (P <0.001). In females, hypothyroid subjects post-thyroxine treatment showed significant difference with euthyroid controls with respect to triglycerides and LDL-cholesterol (P<0.001). Male obese and normal weight hypothyroid subjects (post-thyroxine) differed significantly with respect to LDL-cholesterol, and total cholesterol (significantly higher levels in obese; P <0.001). The obese and overweight groups differed significantly (P<0.001) with respect to LDL-cholesterol. In female hypothyroid subjects post-thyroxine treatment, LDL-cholesterol and triglycerides were significantly higher (p<0.001) in overweight and obese when compared to normal weight females.
Conclusions: Subjects with subclinical hypothyroidism showed significant improvement in dyslipidemia and thyroid hormones on treatment with L-thyroxine.

Subclinical Hypothyroidism; Levothyroxine; Lipid Profile; Body mass Index