International Journal of Clinical Biochemistry and Research


Evaluation of thyroid hormones in chronic kidney disease patients at tertiary care hospital- A comparative study


Full Text PDF Share on Facebook Share on Twitter


Author Details: Bhavika L. Vanani, Dharmesh Nasvantbhai, Hariom Sharma, Sandip R. Patel, Smita Vasava

Volume : 4

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 119

Article End Page : 122


Abstract

Introduction: The study is design to see the association between levels of thyroid hormones (Serum fT3, fT4 and TSH) and renal markers (serum urea, creatinine, and eGFR) in patients of chronic kidney disease (CKD). Hypothyroidism is associated with reduced eGFR while hyperthyroidism results in increased eGFR.
Aim and Objectives: To find out the association between levels of thyroid hormones and markers of renal function in chronic kidney disease (CKD) patients.
Materials and Method: A comparative study was carried out in 100 subjects, more than 18 years of age having chronic kidney disease and a group of 100 normal healthy individuals, age and gender matched from the same population served as controls. Serum urea, creatinine, fT3, fT4 and TSH were measured and glomerular filtration rate was calculated.
Results: In present study around 68% of patients were in stage 5, while 28% and 4% were in stage 4 and in stage 3 of CKD respectively. The most common thyroid hormone derangement observed was low fT3 (p=0.01) and high TSH (p=0.001) in the study group as compared to control group. Low free T3 level (p=0.001) correlated significantly in patients with low eGFR.
Conclusion: CKD is a progressive disease and these patients are more prone to develop thyroid dysfunction, therefore monitoring of thyroid function should be regularly advised to such patients in order to prevent adverse events in relation to kidney and thyroid function.

Keywords
: Chronic kidney disease, Calculated Glomerular Filtration Rate, Thyroid function