International Journal of Clinical Biochemistry and Research


Circulating thyroid hormones with serum uric acid and creatinine in hypo and hyperthyroidism


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Author Details: Hemantha Kumara D.S., Prashanth Kumar B.G., Muralidhara Krishna C.S., H.L. Vishwanath

Volume : 4

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 123

Article End Page : 125


Abstract

Introduction: Thyroid dysfunction is related to damaging effect on glomerular and tubular functions. In recent studies it was found that hypo and hyperthyroidism was accompanied with renal derangement resulting in abnormal levels of serum creatinine and uric acid. So this study was conducted for estimation of serum non-protein nitrogenous constituents in hypo and hyperthyroidism.
Materials and Method: 60 patients, with 30 hypothyroid and 30 hyperthyroid patients were included in this study along with 30 controls. Thyroid hormones (T3, T4, and TSH) were estimated by Beckman coulter Access-2 immunoassay analyser. Uric acid, creatinine and urea parameters were measured using fully automated Beckman coulter clinical chemistry analyser AU480. Analysis of Statistical data was done by SPSS 20.
Results: There was a significant increase in the levels of serum uric acid and (p<0.0001) in hypothyroid patients and hyperthyroid patients showed significant decrease in serum creatinine levels (p<0.0001). When correlated with
TSH, Serum creatinine showed positive correlation, whereas it was negative for serum uric acid in hypothyroidism, in hyperthyroid patients, there was a negative for serum creatinine and uric acid levels.
Conclusion: The results of this study indicate that the non-protein nitrogenous constituent’s mainly uric acid and creatinine were significantly altered in hypothyroid and hyperthyroid patients. Therefore, we have emphasize and the importance of the routine evaluation of these biochemical parameters in hypo and hyperthyroid patients.

Keywords:
Hypothyroidism, Hyperthyroidism, Thyroid Stimulating Hormone (TSH), Creatinine, Uric Acid