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Year 2019

Volume: 6 , Issue: 2

Print ISSN:-2394-6369

Online ISSN:-2394-6377

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International Journal of Clinical Biochemistry and Research


Association of Vitamin D levels and Cognitive function in Postmenopausal women


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Author Details: R. Sudha, R. Kavitha, C. K. Vijayasamundeeswari

Volume : 4

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 164

Article End Page : 167


Abstract

Background: Vitamin D deficiency(VDD) is a major health concern in India, especially in elderly individuals and is adversely associated with neurocognitive function.

Aims and Objectives:

1.        To assess the 25hydroxy vitamin D [25(OH)D] levels in postmenopausal women and compare it with premenopausal women.

2.        To study the association of 25(OH)D levels with markers of cognitive impairment, that is Mini-Mental State examination(MMSE) and Addenbrooke’s Cognitive Examination – Revised(ACE-R) score in postmenopausal women.

Materials and Method: A cross sectional study was conducted on 40 postmenopausal women and 40 premenopausal women as controls. The study subjects were analysed for 25(OH)D levels by ELISA and Cognitive function was assessed by using the MMSE and ACE-R score. Appropriate statistical analysis was done.
Results: Serum 25(OH)D levels (22.3±13.58 ng/ml Vs 32.4±12.4 ng/ml) in postmenopausal women were significantly lower (p-value = 0.03) when compared to the premenopausal women. A significant positive correlation was found between the 25(OH)D levels and the markers of cognitive decline (i.e) MMSE (r = 0.40) and ACE-R score (r = 0.61) in postmenopausal women. Even though the vitamin D levels in premenopausal women were higher than postmenopausal women, a significant proportion(60%) had vitamin D inadequacy.
Conclusion: A significantly lower 25(OH)D levels, MMSE and ACE-R scores were observed in postmenopausal women when compared to premenopausal women. 25(OH)D levels were significantly associated with markers of cognitive decline. These results suggest a potential role of Vitamin D in cognitive dysfunction in postmenopausal women and can be considered as an early marker for cognitive decline.

Keywords:
Cognitive Function, Vitamin D, Postmenopausal Women, Neurocognitive Function