International Journal of Clinical Biochemistry and Research


Non cardiac parameters and their importance in the progression of myocardial ischemia and acute myocardial infarction


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Author Details: Munta Anil Kumar, S.J. Basha, Rama Mani Gorle

Volume : 4

Issue : 4

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 329

Article End Page : 334


Abstract

Introduction: The morbidity and mortality of acute myocardial infarction is rampantly growing worldwide. The infiltration of oxidised lipoproteins in intima of artery results in myocardial ischemia and ends up in AMI if not treated. Thus, the evaluation of risk factors will helps in understanding the ischemia and its progression towards infarction.
Materials and Method: Three groups, control (n=33), ischemia (n=38) and infarction (n=42) were included. The parameters FBS, urea, creatinine, lipid profile and liver function tests were carried out.
Results: All the data seen as mean ± SE. The mean were analysed by (ANOVA) with a post hoc multiple comparison test of student Newman Keuls test. The mean difference was considered as significant at <0.05. The FBS and creatinine, triglycerides and total cholesterol were significantly differed in infarction when compared to control and ischemia. The serum levels of liver enzymes were significant in infarction in comparison to control but no difference was observed between ischemic group and control.
Conclusion: Patients with increased levels of FBS, TAG, LDL and liver enzymes tend to have an increased risk of ischemia and infarction. Therefore in the current study, the assessment of non-cardiac parameters helps to understand the influence on progressive increase of ischemia and infarction compared to healthy individuals as risk factors.

Keywords:
Ischemia, Infarction, Non cardiac markers and Cardiac Markers