International Journal of Clinical Biochemistry and Research


The synergistic role of CKMB mass and high sensitivity Troponin T in the diagnosis of Acute Coronary Syndrome


Full Text PDF Share on Facebook Share on Twitter


Author Details: Mihir Mehta, Simbita Marwah

Volume : 4

Issue : 4

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 374

Article End Page : 378


Abstract

Aim: To determine the synergistic role of CKMB mass (CKMBM) and high sensitivity Troponin T (hs-cTnT) in the diagnosis of Acute Coronary Syndrome (ACS).
Study Design: This was a cross-sectional study comprising of 140 individuals out of which 90 were cases and 50 healthy controls. The study was carried out in a tertiary care hospital between July 2014 to June 2015.
Materials and Method: On the basis of clinical history and 12 lead electrocardiogram initial diagnosis of acute coronary syndrome was made in the cases. High sensitivity troponin T and CKMB mass was measured in all the individuals.
Results: The sensitivity, specificity, positive and negative predictive value is 80.3%, 86.2%, 92.4% and 67.5% in case of CKMBM, while it is 98.3%, 65.5%, 85.7% and 95% in case of hs-cTnT, while the area under curve in case of CKMBM is 0.832 and in case of hs-cTnT is 0.819.
Conclusions: Thus, we have concluded that hs-cTnT and CKMBM correlate well in the diagnosis of ACS. But hs-cTnT can detect false positive cases which can be avoided by using CKMBM along with hs-cTnT in the diagnosis of ACS.

Keywords:
Acute coronary syndrome, High sensitivity troponin T, CKMB mass, Sensitivity, Specificity