International Journal of Clinical Biochemistry and Research


Study of endogenous hormones in breast cancer patients of premenopausal Women


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Author Details: GSR Kedari, PM Abraham Sam Rajan, Ratnashree Biswas

Volume : 4

Issue : 4

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 400

Article End Page : 404


Abstract

Introduction: Several studies were conducted worldwide to estimate various endogenous hormone levels in breast cancer patients of post-menopausal women and very few studies were done in premenopausal women. In India, our study is the first study conducted to estimate the endogenous hormones in breast cancer patients of premenopausal age group.
Materials and Method: 50 breast cancer patients of premenopausal age group were taken as cases and 75 age matched controls were selected for this study. Total testosterone, follicular estrogen, mid luteal estrogen, luteal estrogen, follicular progesterone, mid luteal progesterone, luteal progesterone were estimated for all the subjects.
Results and Conclusion: Statistical significant increase was observed in the levels of testosterone in cases when compared to controls. Statistical significant difference was observed in the levels of follicular progesterone between cases and controls. No statistical significant difference was observed in other parameters between cases and controls.

Keywords:
Premenopausal women, Testosterone, Estrogen, Progesterone