International Journal of Clinical Biochemistry and Research


Use of salivary liver function markers for the prognosis of deaddiction in alcohol dependent non-smokers and smokers: A before and after study


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Author Details: JB Honnamurthy, Shivashankara AR, Avinash SS, John P Mathai, Malathi M

Volume : 5

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 35

Article End Page : 40


Abstract

Alcohol deaddiction improves the liver function markers in blood as well as saliva in both smokers and non-smokers. The study was conducted to observe the changes in liver function markers after deaddiction in both blood as well as saliva. The study included 83 alcohol dependent subjects, among whom 45 were smokers and 38 were non-smokers. They were followed up after deaddiction for 19-21 days. The liver function markers GGT- γ glutamyl transferase, AST- Aspartate transaminase, ALT- Alanine transaminase, TP- Total protein, and Alb-Albumin were measured spectrophotometrically before and after deaddiction in saliva as well as blood. Paired‘t’ test was done to analyse the significance of their changes in before and after deaddiction. There was no difference in NR (normalization rate) of GGT, AST and ALT between alcohol dependent smokers and non-smokers in saliva as well as blood. NR of TP and Alb was better in non-smokers compared to smokers. GGT (p<.001), AST (p<.001) and ALT (p<.001) have decreased and SFR has increased significantly in all groups after withdrawal. Elevation after withdrawal of TP and Alb were not significant. Elevation of Alb after withdrawal was not significant. In both alcohol dependent smokers as well as non-smokers, salivary GGT (p<.001), AST (p<.001) and ALT (p<.001) levels can be used instead of blood levels to monitor the prognosis of deaddiction, but TP and Alb cannot be used for the same.

Keywords: Aminotransferases, Alcohol withdrawal, Alcohol dependence, γ-glutamyl transferase.

Doi :-https://doi.org/10.18231/2394-6377.2018.0008