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International Journal of Clinical Biochemistry and Research


Assessment of glycated hemoglobin and uric acid level in polycystic ovarian syndrome in a Tertiary Care Institute of Marathwada region


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Author Details: Sunita M. Aghade, Jayashree S. Bavikar

Volume : 5

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 49

Article End Page : 53


Abstract

Introduction: The Polycystic Ovary Syndrome (PCOS) is one of the most common reproductive endocrine disorders, affecting 5–10% of women in the reproductive age. Insulin resistance is the hallmark of this disorder. PCOS has been epidemiologically linked to an increased risk for type 2 diabetes mellitus and cardiovascular diseases. The present study was planned to study glycated hemoglobin (HbA1c) and uric acid level in patients of PCOS. 
Materials and Methods: The study comprised of 60 women with PCOS as cases and 60 healthy females as controls. HbA1c and uric acid level were measured in all participants. 
Results: Glycated hemoglobin and serum uric acid were significantly increased in PCOS group and showed positive correlation with body mass index and waist: hip ratio. The prevalence of raised HbA1c was 40% in PCOS women.
Conclusion: In our study we found significant alterations in HbA1c and uric acid level in cases of PCOS. Early identification of these changes and timely intervention can reduce morbidity due to type 2 diabetes mellitus and cardiovascular diseases in PCOS. This will help to redefine the paradigms of PCOS care in India.

Keywords: Cardiovascular Disease, HbA1c, PCOS, Type 2 Diabetes Mellitus, Uric Acid.

Doi :-https://doi.org/10.18231/2394-6377.2018.0011