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International Journal of Clinical Biochemistry and Research


LEVEL OF SERUM URIC ACID IN PREECLAMPSIA


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Author Details: Ramesh Chandra Thanna, Rekha Choudhary, Swati Pathak, Amrita Vamne, Shreya Nigoskar

Volume : 2

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 120

Article End Page : 122



Abstract

Background: Uric acid is the final product of the purine metabolism in humans. The 2 final reactions in its production which catalyze the conver-sion of hypoxanthine to xanthine and the latter to uric acid are catalyzed by the enzyme xanthine oxidoreductase. The role of uric acid in the progression of prediabetes to diabetes has been known. Serum uric acid has been shown to be associated with cardiovascular disease, hypertension, and chronic kidney disease.
Aims & objectives: The present study was done to see the level of uric acid in preeclampsia and regnancy induced hypertension (PIH) patients.
Material and Methods: The study involves 50 cases of preeclamsia of age group between 20-35 year and 50 controls with similar age group.Srum uric acid was done from all subjects by uricase method in semi-automated biochemistry analyser after centrifugation of samples.
Results: The observed mean serum uric acid levels in preeclampsia was 7.48±0.59 mg/dl as compare to 4.12±0.59 in control group. The difference between them is highly significant because p-value is less than 0.05.
Conclusion: High serum uric acid level could be a useful indicator of the maternal and fetal complication.

Key words: Uric acid, Preeclampsia, Pregnancy