International Journal of Clinical Biochemistry and Research


Evaluation of iron profile in type 2 diabetes mellitus patients of tertiary care center of central India


Full Text PDF Share on Facebook Share on Twitter


Author Details: Gajendra Singh Dhakad,Ashish Kumar Sharma*,Gulab Kanwar,Ajay Kumar Singh,Shrikant Sharma

Volume : 6

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 15

Article End Page : 19


Abstract

Introduction: Iron profile is one of the most important indexes for good health. Altered iron profile is a risk factor for many diseases. Excessive iron accumulation in body causes damages of many cellular structures and leads to oxidative damage and causes many complications. So, Iron profile must be studied in many diseases like diabetes mellitus.
Materials and Methods: 100 subjects were taken in this study, out of which 50 were type 2 diabetes and 50 were normal healthy controls. BMI was calculated by dividing body weight (Kg) to square of height (meters). The waist / hip circumference ratio was calculated by dividing the waist circumference (cm) to hip circumference (cm). Sphygmomanometer was used for blood pressure measurement. The serum iron, TIBC, UIBC, plasma glucose and HbA1c were measured by semiautoanalyzer. The serum ferritin was estimated by chemiluminescence method. The % transferrin saturation was calculated by formula serum iron (?g/dl) x 100/ TIBC (?g/dl).
Result: The anthropometric parameters like weight, BMI, waist circumference, hip circumference, waist hip circumference ratio, systolic and diastolic blood pressure was statistically extremely significantly (p<0> increased in type 2 diabetes mellitus subjects as compared to healthy control subjects. The plasma fasting glucose, HbA1C, serum iron, % saturation and serum ferritin were statistically extremely significantly (p<0> increased and UIBC was statistically extremely significantly (p<0> decreased while TIBC and hemoglobin were statistically significantly (p<0>
Conclusion: Elevated iron and ferritin is a risk factor for diabetes and produce many complications. Proper management must be taken to remove the excess iron that can be very harmful to the body.

 Keywords: T2DM, Iron, Radical, Ferritin, Insulin resistance, Oxidative stress.

Doi :-https://doi.org/10.18231/2394-6377.2019.0005