International Journal of Clinical Biochemistry and Research


Heritability of hypoadiponectinemia in first-degree relatives of Indian population


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Author Details: Geetha Bhaktha*,Shivananda Nayak,Manjula Shantaram,Shreemathi Mayya

Volume : 6

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 48

Article End Page : 52


Abstract

Objective: Diabetes is a disorder and prevention has become a global priority. Significance of hereditary factor in the advancement of Diabetes mellitus is really convincing. Sensitive factor for developing Type 2 diabetes (T2DM) is identified as adiponectin and hence the need of the study.
Materials and Methods: This is a cross-sectional study. Subjects with self-reported history of T2DM in both parents were selected and biochemical parameters with anthropometric were recorded. They were grouped as diabetic and non-diabetics.
Result: A greater level of difference of 9.45 units was seen in adiponectin levels between presence and absence of family history of diabetes (FHD). Further adiponectin continued to witness a significant difference even in diabetics and normal group with respect to family history. Hence when linear regression was made to asses relationship between adiponectin and other variables, it was found that diabetic status (P =0.000), leptin (P =0.001), and FH (P =0.000) had reached statistical significance among others parameters. Moreover adiponectin was positively correlated with diabetic status (B=4.655) and negatively correlated with leptin (B= -0.125) and Family History (B= -9.034).
Conclusion: The comprehensive relation between Family History and adiponectin is true and are inversely related. Hence the impact of familial predisposition is advocated due to genetic load and diabetic status.

Keywords: Adiponectin, Family history, Hyopoadiponectinemia.

Doi :-https://doi.org/10.18231/2394-6377.2019.0013