International Journal of Clinical Biochemistry and Research


Oxidative stress in beedi rolling pregnant women and their newborns


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Article Type : Research Article

Author Details: Astagimath MN,Veena A*

Volume : 6

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 138

Article End Page : 142


Abstract

Introduction: Though it is knows that tobacco consumption and exposure to environmental tobacco smoke causes health hazards there is no parameter that can predict the extent of damage in pregnant women. There is no parameter that measures the fetal exposure to toxic of cigarette smoke.
Objective: To study oxidative stress in beedi rolling pregnant women and their newborns.
Materials and Methods: The study group consists of 36 mothers, 36 newborns and the control group consists of 10 mothers and 10 newborns. The cases were the pregnant women who were exposed to nicotine. The controls were the pregnant women who were not exposed. Estimation of TBARS was done by oxidative lipid peroxidation and non –oxidative lipid peroxidation methods.
Results: In this study it was observed that the duration of tobacco free period before delivery showed significant negative correlation with the serum cotinine levels. The duration of beedi rolling showed negative correlation with the serum cotinine levels. There was no relation found between either the duration of beedi rolling or the tobacco free period and lipid peroxidation levels. The above findings may be due to the adaptive changes in the metabolism of nicotine.
Conclusion: From the study it appears that there may not be much role of oxidative stress in the causation of low birth weight through the increased production of lipid peroxides or oxidative stress, but it cannot be rules out that tobacco exposure thought beedi rolling is a causative factor.

Keywords: Oxidative stress, Adaptive changes, Pregnancy, Serum cotinine.

Doi :-https://doi.org/10.18231/j.ijcbr.2019.033