International Journal of Clinical Biochemistry and Research


Sialic acid: an early sensitive marker improves detection of nephropathy in type-2 diabetes mellitus patients


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Article Type : Research Article

Author Details: B Sheshu Kumar,Siraj Ahmed Khan,K S.S Sai Baba,P V. Satyanarayana,Iyyapu Krishna Mohan*

Volume : 6

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 152

Article End Page : 156


Abstract

Introduction: Diabetic nephropathy has become the single most important cause of end stage renal disease worldwide. Detection of early stages of diabetic nephropathy with sensitive tests may be useful to prevent progression of nephropathy. The present study was undertaken to study the serum sialic acid levels and microalbuminuria and to assess whether there is a relationship between these two with glycemic control and other parameters in diabetic nephropathy patients.
Materials and Methods: A total number of 100 subjects participated in present study including 50 clinically diagnosed cases of type-2 diabetic nephropathy patients. Fasting and post-prandial blood sugar, urea, creatinine, serum sialic acid and urinary microalbumin levels were estimated.
Results: The mean fasting blood sugar values in cases (181.40±45.82) as compared to controls (89.62±12.53) is statistically significant (p<0 xss=removed xss=removed xss=removed xss=removed> Conclusion: Estimation of serum sialic acid prior to microalbumin in diabetic patients is helpful in assessing the glycemic control and identify the risk of nephropathy which is the main cause for mortality and morbidity among type-2 diabetes mellitus patients.

Keywords: Serum sialic acid, Microalbumin, HbA1c, Nephropathy, Type-2 diabetes mellitus.
 

Doi :-https://doi.org/10.18231/j.ijcbr.2019.036