International Journal of Clinical Biochemistry and Research


Is adenosine deaminase level a predictive biochemical marker of type II diabetes mellitus in obese Indian subjects


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Article Type : Research Article

Author Details: Anuradha Rathore Jain*,Ameya Kumar,Tripti Saxena,Anita Arya,Ashish Anantrao Jadhav

Volume : 6

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 165

Article End Page : 169


Abstract

Objective: To evaluate serum Adenosine Deaminase (ADA) levels in obese and non obese Type II Diabetes Mellitus (T2DM) and compare it with healthy controls (obese and non obese).
Materials and Methods: Total 100 subjects were included in the study. Fasting blood sugar (FBS) and ADA activity along with other routine biochemical parameters were determined in their serum. Based on their BMI and FBS level study subjects were divided into four groups: Control, Obese, Non obese T2DM and Obese T2DM. 
Results: ADA activity was significantly increased (P < 0> Conclusion: In this study we observed an increased ADA activity in obesity and T2DM. A close relation may be present between insulin resistance produced in obese subjects and diabetics. Therefore ADA could therefore be used in routine lab investigations, especially in obese patients as a predictive marker for assessing the development of insulin resistance and hence diabetes.

Keywords: Diabesity, ADA, Obesity, Insulin resistance, Fasting blood sugar.
 

Doi :-https://doi.org/10.18231/j.ijcbr.2019.039