International Journal of Clinical Biochemistry and Research


Biochemical evaluation of hypothyroidism and euthyroid state in cases of pregnancy by the estimation of T3, T4 and TSH


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Article Type : Research Article

Author Details: K Maria Kumar*,Vijaya Kumari,P Sateesh

Volume : 6

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 200

Article End Page : 208


Abstract

Introduction: Thyroid diseases are not uncommon in women of reproductive age with an estimation of 5-15%. The thyroid gland must produce 50% more thyroid hormone in pregnancy in order to maintain euthyroidism and for foetal wellbeing.
Aims and Objectives: To study the effect of hypothyroidism in pregnant women, attending for ante-natal check-up to the dept. of OBG – GGH, Guntur.
Inclusion Criteria: Pregnant women with hypothyroidism with or without treatment, pregnant woman in euthyroid state.
Exclusion Criteria: Pregnant women with hyperthyroidism, smoking alcoholism, chronic infections, systemic illness and diabetes/impaired glucose tolerance and hypertension.
Materials and Methods: Singleton pregnant women aged ? 18 years TSH >2.5µIU/ml in first trimester and TSH >3µIU/ml in second and third trimester with normal T4 levels are included as cases. Controls are age and trimester matched healthy first, second and third trimester, singleton euthyroid pregnant women.
Results: The present study was carried out on age matched 120 pregnant women of which 60 are hypothyroid and 60 are euthyroid. Out of 60 cases 3 cases (5%) are with overt hypothyroidism and 57 cases (95%) are with subclinical hypothyroidism.

Keywords: Overt thyroid, Subclinical thyroid, TSH-Thyroid stimulating hormone, Chemiluminescence, Maternal serum sample.

Doi :-https://doi.org/10.18231/j.ijcbr.2019.045