International Journal of Clinical Biochemistry and Research


Evaluation of estimated glomerular filtration rate (egfr), serum creatinine, urea and electrolytes profile levels in diabetic patients attending medical outpatient clinic in Nnamdi Azikiwe University teaching hospital, Nnewi, Anambra State, Nigeria


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Article Type : Research Article

Author Details: Ihim Augustine Chinedu,Analike Rosemary Adamma,Chibuike Standhope,Ogbodo Emmanuel Chukwuemeka*,Asomugha Azuoma Lasbrey

Volume : 6

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 217

Article End Page : 221


Abstract

This case control study was aimed at evaluating the estimated glomerular filtration rate (egfr), serum creatinine, urea and electrolytes profile levels in diabetic subjects attending medical outpatient clinic, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria. The protocol for the study was explained to the prospective subjects and those who gave informed consent were recruited. . A total of 114 subjects comprising of 57 diabetic subjects and 57 controls aged between 40 and 73 years were recruited for the study. The patients and controls were aged and sex matched. Thereafter, 5mls of blood sample was collected from each subject into plain container for estimation of biochemical parameters. Serum creatinine and urea were assayed by colorimetric method. The eGFR was calculated using the Modification of Diet in Renal Disease (MDRD) formula while serum electrolytes (Na+, K+, Cl- and HCO3-) were determined using Ion Selective Electrode (ISE). Statistical Package for the Social Sciences (SPSS) version 21.0 was used for the analysis of the data obtained using Students’t-test and pearson correlation and presented as mean ± standard deviation (SD). The results revealed a significant decreases in the mean serum levels of eGFR, Creatinine and bicarbonate in diabetic subjects than in the control (p<0>0.05) respectively. Also, no significant differences were observed between both male and female subjects in the parameters studied (p>0.05). There was also a strong negative correlation between serum sodium and eGFR, as well as between creatinine and eGFR in the diabetic subjects (r = -0.016, -0.930 respectively), (P<0>


Keywords: Diabetes mellitus, Kidney disease, Estimated Glomerular Filtration (eGFR), Creatinine, Urea, Electrolytes. 

Doi :-https://doi.org/10.18231/j.ijcbr.2019.048