International Journal of Clinical Biochemistry and Research

Can serum leptin be a predictor of cardiovascular risk in non-obese polycystic ovarian syndrome?

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Article Type : Research Article

Author Details: Prerna Chandrakishore Chandak,Madhur Gupta*

Volume : 6

Issue : 2

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 226

Article End Page : 229


Introduction: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of unknown etiology affecting approximately 7% of the women in reproductive age.It is generally characterized by menstrual irregularity, subfertility, hirsutism, acne and abnormal biochemistry with raised serum testosterone, androstenedione, and insulin and luteinizing hormone levels. Leptin regulates energy homeostasis, neuroendocrine function, and metabolism.There is a direct relationship that exists between serum leptin and insulin resistance which forms a traditional risk factor for cardiovascular risks mainly including atherosclerotic vascular disease.
Material and Methods: A group of 30 non-obese women suffering from polycystic ovarian syndrome were considered. Their blood samples were collected and tested for serum leptin, insulin and blood glucose. The values were correlated with BMI (body mass index) values and the conclusions were made.
Result: Mean serum leptin level recorded was 4.929 ng/ml and the HOMA value ranged from 1.5- 3.0. The Pearson’s Correlation Coefficient was +1.00, which indicates a positive relationship between the two values. 
Conclusion: We report that there is a direct relationship between serum leptin levels in females suffering from polycystic ovarian disorder. This information can be used to assess the risk of cardiovascular disorders in these particular subjects.

Keywords: Polycystic ovarian syndrome, Serum leptin, insulin, Cardiovascular risk. 

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