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IP Indian Journal of Conservative and Endodontics


Biomarker of health and disease in Dentistry: Proteomics


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Article Type : Review Article

Author Details: Vamsee Krishna N*,Madhuri Nadhamuni

Volume : 4

Issue : 3

Online ISSN : 2581-8988

Print ISSN : 2581-9534

Article First Page : 69

Article End Page : 74


Abstract

Every living organism contains ‘Proteins’ which are building blocks to perform various functions. Proteomics is the analysis of the whole protein in a genome which tells about the molecular mechanisms of homeostatic cell and regarding external disturbances, such as pathologic or pharmacologic treatment. Proteomics improvized various biomedical fields such as medicine, dentistry, molecular biology, and genetics. This article reviews some of the currently available literature on conducting Proteomic analysis of dental tissues. A literature review is done using electronic databases, such as “PubMed,” “Google Scholar,” and “Scopus,” using keywords “Proteomics,” and “Biomarkers.” Furthermore, an advanced or refined search was carried out using the keywords “Mass Spectrometry,” “Proteins,” “Enamel,” “Dentin,” “Cementum,” “Periodontal ligament” and “pulp.” Proteomics in dentistry helps in the early diagnosis of health-disease molecular signatures with the discovery and recognition of numerous biomarkers in biological, pathological or pharmacological processes that are present in the fluids of the oral cavity. This paper explains the role of proteomics in the analysis of oral tissues.

Keywords: Proteomics, Mass Spectrometry, Biomarkers.

Doi :-https://doi.org/10.18231/j.ijce.2019.016