Print ISSN:-2581-4710

Online ISSN:-2581-4729

CODEN : IIJCBS

Current Issue

Year 2019

Volume: 5 , Issue: 4

Article view: 836

Article download: 165

IP Indian Journal of Clinical and Experimental Dermatology


A comparative study of methotrexate & low molecular weight heparin for the treatment of generalized lichen planus


Full Text PDF Share on Facebook Share on Twitter


Author Details : Snehal Lunge, Shivakumar Patil, BS Manjunathswamy

Volume : 2, Issue : 4, Year : 2016

Article Page : 153-158


Suggest article by email

Abstract

Background: Lichen planus is a difficult condition to treat and is often disappointing for dermatologist. Many a times it’s associated with relapse. There is long list of topical & systemic therapies for its treatment.
Aim & Objectives: the objective of this study was to compare the efficacy and safety of methotrexate and low molecular weight heparin in generalized lichen planus patients along with 6 months follow up. In this study 40 patients with generalized lichen planus were enrolled after basic evaluation 20 patients(11 males, 9 females) were started on low dose methotrexate & 20 patients(11 males, 9 females) on low molecular weight heparin. The response rate were appraised after once a week for 16 to 24 weeks for both methotrexate & low molecular weight heparin. Six month follow up was done for evaluating the recurrence rate.
At the end of 16 to 24 weeks of treatment with methotrexate 19 of 20 patients showed 90% improvement, 1 patient did not tolerate methotrexate after 4 weeks because of its adverse effects. Only 3 patients were showed relapse after discontinuation of therapy at 3, 2.6, 2 months respectively.
At the end of 16 to 24 weeks of treatment with low molecular weight heparin complete remission of skin lesions in 13 of 20 patients with 80% improvement. Also 7 patients showed relapse after discontinuation of therapy at 2, 3, 3.6, 1.6, 4, 2, 6 months respectively.
Conclusion: Overall we want to emphasized that low dose oral methotrexate is effective & is a reasonably safe option for generalized LP. There was better tolerance by patients with low recurrence rate than subcutaneous low molecular weight heparin.

Keywords: 
Generalized Lichen planus, Methotrexate, Low molecular weight Heparin

How to cite : Lunge S, Patil S, Manjunathswamy B, A comparative study of methotrexate & low molecular weight heparin for the treatment of generalized lichen planus. IP Indian J Clin Exp Dermatol 2016;2(4):153-158

Copyright © 2016 by author(s) and IP Indian J Clin Exp Dermatol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)