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IP Indian Journal of Clinical and Experimental Dermatology

Sweet’s syndrome: A Therapeutic challenge

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Article Type : Case Report

Author Details: Krishnendra Varma,Richa Rokde*

Volume : 5

Issue : 2

Online ISSN : 2581-4729

Print ISSN : 2581-4710

Article First Page : 174

Article End Page : 175


Sweet syndrome (acute febrile neutrophilic dermatosis) is not a common disease, etiology of which is unknown. It is an inflammatory neutrophilic dermatosis characterized by non?itchy, tender, erythematous papules and plaques most commonly distributed on the arms, upper body, head and neck. It commonly affects adults in between 30- 60 years with female predominance with 4:1 sex ratio. The disease is associated with fever, peripheral leukocytosis and wide variety of diseases. It shows excellent response to systemic corticosteroids. A 28 year old female presented with multiple red elevated lesion over face, back, upper and lower limbs, which were associated with pain and fever. She gave history of sore throat before appearance of lesions. On cutaneous examination erythematous papules and plaques, plaques were studded with pseudovesicles were seen on face, back, upper and lower limbs. They were tender and associated with fever. Patient underwent clinical and systemic examination followed by routine and histopathological investigations. Complete blood picture showed neutrophilia (94%) and histopathological examination showed dense neutrophilic infiltrate with oedema in dermis. The patient was prescribed topical steroids, oral Dapsone and corticosteroids, but patient did not show any improvement. Later on patient was put on Dexamethasone pulse therapy along with oral Azathioprine for 18months. Lesions resolved and no recurrence was observed in months.

Keywords: Sweet syndrome, Neutrophilic dermatosis, Recurrent.

Doi :-https://doi.org/10.18231/j.ijced.2019.037