Indian Journal of Clinical and Experimental Ophthalmology

Comparative effectiveness of commonly used drugs in primary open angle glaucoma in Indian eyes

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Author Details: Atul Kumar Singh, Hari Kumar, MK Singh

Volume : 3

Issue : 1

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 20

Article End Page : 23


Aim: Objective of this study to compare effectiveness of first line of topical drugs commonly used in POAG and to see the percentage of the IOP lowering effect of different drugs in Indian eyes.
Design: This study was conducted in one of the zonal hospital in north India. The study design was a randomized control trial and sample size of 60 patients was included.
Methods: We included Randomized controlled trial of three commonly used drugs (Latanoprsot, Timolol, Brimonidine) for established cases of POAG, NTG and Pigmentary Glaucoma. Patients were followed up for 06 months and IOP recording was done in phase manner for four visits. Data were analyzed using SPSS software over 15.0.
Results: At the end of six months, Latanoprost eye drops have the highest percentage of reduction (33%), compare to Timolol (27%) and Brimonidine (25%) group. Latanoprost eye drops also have better patient compliance as a once a day regime.
Conclusion: All active first line of drugs is effective in lowering intraocular pressure at the end of 06 months. However Latanoprost eye drops has greater IOP reduction compared to Timolol and Latanoprost group. All these drugs can be chosen as a first line of drugs depending upon patient age factor, the degree and type of glaucoma, compliance of drugs, cost and side effect of these drugs.

: Brimonidine, Glaucoma, Indian eyes, Latanoprost, Timolol