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Indian Journal of Clinical and Experimental Ophthalmology

Study of retinal nerve fiber layer and foveal thickness in amblyopia

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Author Details: Shivam Sood, Amit Maitreya, Renu Dhasmana

Volume : 3

Issue : 1

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 66

Article End Page : 68


Aim: To measure and compare the retinal nerve fiber layer (RNFL) and foveal thickness of normal and amblyopic eyes in unilateral amblyopia.
Material and Methods: This was a prospective, observational cross-sectional study conducted over a period of one year, after approval from the Institutional ethical committee. Children presenting to the pediatric ophthalmology clinic with a diagnosis of unilateral amblyopia due to anisometropia or strabismus or both were included. All children underwent clinical examination including BCVA, anterior and posterior segment examination and squint workup in cases of strabismus. Retinal nerve fiber layer (RNFL) and foveal thickness were measured in amblyopic as well as normal eye by Optovue RTvue 100 Fourier domain OCT.
Statistics: The Student t-test was used to compare the RNFL and foveal thickness in the normal and amblyopic eye.
Results: The study included 31 children out of which 16 (51.62%) were male and 15 (48.38%) female. Mean age of presentation was 11.29±3.06 years. There were 58.06% with anisometropic, 22.58% with strabismic and 19.36% subjects with mixed amblyopia. The mean foveal thickness of normal eyes was 254.64±35.57 μm whereas that of corresponding fellow amblyopic eyes was 271.29±28.08 μm with a p-value of 0.045. The mean RNFL was thicker in the normal eyes (111.06±17.63 μm) than the fellow amblyopic eye (108.80±23.50 μm) but this difference was not statistically significant (p=0.670).
Conclusion: Foveal thickness was found significantly more in the amblyopic eye than fellow normal eye whereas the RNFL thickness showed no statistically significant difference between the two groups.

Retinal Nerve Fiber Layer, Foveal Thickness, Amblyopia, OCT