Indian Journal of Clinical and Experimental Ophthalmology


Peri-papillary retinal nerve fiber layer thickness analysis in pre-clinical diabetic retinopathy using optical coherence tomography


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Author Details: Manjunath B. H., Sunitha M. N. Gowda, Shruti P. Choudhari

Volume : 3

Issue : 2

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 122

Article End Page : 124


Abstract

Introduction: Diabetic retinopathy is one of the leading causes of blindness according to vision 2020 protocol. There is evidence of structural changes prior to clinically detectable vascular complications. With newer technologies, like optical coherence tomography (OCT) it is possible to obtain optical section biopsies and it aids in quantifying the effects of diabetic retinopathy on the retinal nerve fibre layer thickness.
Objectives: To establish the role of OCT in evaluating the RNFL thickness in diabetics without clinically evident diabetic retinopathy.
Materials and Methods: This study presents a total of 60 eyes of 60 patients attending the OPD at Bapuji hospital and Chigateri general hospital attached to J.J.M medical college, Davangere from September 2014 to September 2016. All patients were subjected to RNFL analysis using OCT.
Results: In our study, we found a tendency towards thinning in RNFL thickness globally and significant RNFL thinning in the superior quadrant with increasing duration of diabetes (<5 years-120.24±17.54 and > 5 years-112.88±19.63). No significant change was observed with other variables.
Conclusion: OCT may be used to detect earlier signs and structural changes of DR, leading to earlier diagnosis and intervention. The RNFL loss in diabetics without retinopathy could be an indicator of likely neuronal loss in early DR. Further clarifications are required in this regard, we believe that OCT measurements may be one of the useful methods to elucidate the characterization of early structural changes of DR.

Keywords:
Diabetic retinopathy (DR), Retinal nerve fibre layer thickness, OCT