Indian Journal of Clinical and Experimental Ophthalmology


Comparison of efficacy of olopatadine hydrochloride 0.1% and azelastine hydrochloride 0.05% eye drops for treatment of allergic conjunctivitis in rural South India


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Author Details: Vijay Kumar Srivastava, Kunal Verma

Volume : 3

Issue : 2

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 207

Article End Page : 209


Abstract

Introduction: Conjunctival inflammation due to allergy is known as allergic conjunctivitis. Common ocular symptoms may be itching, swelling of eyelids, watering, watery discharge, photophobia and foreign body sensation.
Aims and Objectives: To Compare the efficacy of Olopatadine Hydrochloride 0.1% and Azelastine Hydrochloride 0.05% Eye drops for Treatment of Allergic Conjunctivitis in Rural South India.
Methodology: A prospective clinical trial in 74 patients was carried out. Patients by random selection were given treatment by Olopatadine Hydrochloride 0.1% and Azelastine Hydrochloride 0.05% eye drops. Patients were assessed by ophthalmologist 0, 3rd, 7th and 14th day after starting treatment. During visits the symptom were graded from zero to three scale.
Result: The mean age in Olopatadine group was 18± 3.6 years and in Azelastine group was 19± 4.4 years. There were 26 Males and 11 Females in Olopatadine group and 28 Males and 9 Females in Azelastine group. The mean values for the duration of disease in both the groups were 2.8± 2.2 months and 2.9± 2.4 months respectively in Olopatadine and Azelastine group. The symptoms were compared in the two groups on 3rd, 7th and 14th day after starting treatment. The score given by the Ophthalmologist were markedly lower in both groups after treatment during all visits. (P<0.05).
Conclusion: Both Olopatadine and Azelastine reduced symptoms of allergic conjunctivitis very significantly however Olopatadine was more effective.

Keywords:
Allergic Conjunctivitis, Olopatadine Hydrochloride, Azelastine Hydrochloride