Indian Journal of Clinical and Experimental Ophthalmology

Evaluation of dry eye disease in patients with diabetic retinopathy

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Article Type : Research Article

Author Details: Rimsha Thaseen*,Rahul Sahay,Shilpa Goyal,Anuj Khullar,Dharmendra Singh

Volume : 5

Issue : 2

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 193

Article End Page : 197


Introduction: Due to lack of correlation between symptoms and signs in dry eye disease, changes in tear film parameters and ocular surface health have shown wide variance across different studies worldwide. The present study evaluated the efficacy Schirmer, tear film break-up time (TBUT) and conjunctival impression cytology (CIC) in type 2 diabetics with retinopathy.
Materials and Methods: The scoring of Schirmer test, TBUT, and CIC was compared in 75 eyes of diabetics with retinopathy and 75 eyes of age and sex matched healthy controls. The diagnostic accuracy of these test for dry eye diagnosis was estimated using receiver operating curve (ROC) analysis.
Results: Dry eye indices showed a significant reduction (P<0 P=0.645), P=0.478), P=0.676) P=0.345) AUC=0.982)>TBUT (AUC=0.948) >Schirmer (AUC= 0.864), respectively.
Conclusion: Tear film characteristics and ocular surface health in patients with type 2 diabetes mellitus with retinopathy include decreased tear production as well as tear film stability with worse Nelson grade (squamous metaplasia), respectively. Second, the accuracy of CIC to evaluate dry eye in patients with diabetes was higher as compared to TBUT and Schirmer. All diabetic patients should be examined for tear film and ocular surface changes irrespective of the stage of retinopathy.

Keywords: Conjunctival impression cytology, Dry eye, Receiver operating curve, Schirmer Test, Tear film break-up time, Type 2 retinopathy.

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